Pancreatic cancer ‘time machine’ exposes plot twist in cell growth and invasion

WEST LAFAYETTE, Ind. — Pancreatic cancer has one of the worst survival rates among cancers. Patients can expect as low as a 9% chance to live for at least five years after being diagnosed. Going back in time to observe how cells with key gene mutations interact and become invasive would help researchers better understand how the cancer starts and identify it sooner. A pancreatic cancer “time machine” engineered by Purdue University researchers has revealed that the disease is even more unpredictable than previously thought: Cancer cells promote each other’s invasiveness when they grow together. The study, published in the journal Small, is just the beginning of a new discovery about how pancreatic cancer evolves. Since the paper’s publication, the researchers also have found drug resistance in cancer cell types originating from two drug-sensitive ones. The time machine is a hollow tube of collagen that realistically mimics the microanatomy of a pancreatic duct. By injecting cancer cell lines into microfluidic channels within the artificial duct, the researchers can use the system as a model for observing how pancreatic cancer behaves over time. Typically, it takes 10-20 years f...

Zelda: Link’s Awakening Beginner’s Guide: 9 Spoiler-Free Tips To Get You Started

The recently released The Legend of Zelda: Link’s Awakening on Nintendo Switch is a remake of the Game Boy classic, but that doesn’t mean it’s exactly the same game you remember from all those years ago. A lot has changed since the halcyon days of your youth because this Zelda cult classic has been given a major facelift. Aside from a major visual overhaul, there are a few notable quality-of-life improvements that help make the game easier to digest for modern audiences, such as additional equipable item slots and the ability to refer to previous conversations. However, if you’ve never played the original Link’s Awakening or it has been a while, the remake may leave you somewhat disoriented. Below we’ve gathered nine spoiler-free tips to help you along your adventure. Check out the table of contents below to get to exactly what you’re looking to know. Alternatively, you can check out our guides to heart piece locations and secret seashell locations. For more Link’s Awakening, be sure to check out our video feature comparing the remake and the original. In GameSpot’s Link’s Awakening review, critic Peter Brown gave the g...